Gastrointestinal (GI): NSAIDs that block COX-1 action have correlations with GI difficulties because of the inhibition on the synthesis of gastroprotective agents including PGE2 together with other prostaglandins. This inhibition results in diminished mucin output by gastric epithelial cells, significantly less bicarbonate secretion, and fewer epithelial mobile turnover, among the https://glennr468wyx2.hyperionwiki.com/user