Pentobarbital will decrease the extent or impact of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown. Psychological, tolerance and Actual physical dependence might arise with ongoing use; people with psychological dependence on barbiturates may acquire a Actual physical dependence on barbiturates by increasing or decreasing the dosage inte... https://wardo998gsd0.lotrlegendswiki.com/user