Comment: Barbiturates may possibly maximize adverse effects, which includes respiratory melancholy, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. pentobarbital will decrease the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib ... https://chrisz110ods7.answerblogs.com/profile